The year is 1480, and celebrated Florentine lawyer Guid'Antonio Vespucci and his nephew, Amerigo, return home to Italy from a government mission to find their dreams of peace shattered. Marauding Turks have abducted a beautiful young girl and sold her into slavery. Equally disturbing, a revered painting of the virgin Mary is weeping in Guid'Antonio's family church. Angry and fearful Florentines interpret these stunning events as signs of God's wrath for their support of the city's leader, Lorenzo de'Medici, and Lorenzo's refusal to end his war with the Pope. Faced with losing control of the city, Lorenzo enlists Guid'Antonio, his friend and stauch political ally, to investigate the tears.